This year’s support from the Swedish Research Council encouraged MultiPark’s ambition to be a multidisciplinary research area. Projects ranging from experimental investigations to clinical cohorts and health science-related questions received substantial support.
Congratulations to:
Angela Cenci Nilsson for her project “Mapping and treating circuit dysfunctions in Parkinson’s disease.”
The project will produce rodent models mimicking different dysfunctions and pathologies that are known to occur in the brain of Parkinson’s patients. These models will be used to investigate mechanisms underlying the observed dysfunctions and evaluate different potential treatments.
We will investigate mechanisms underlying dysfunctions in Parkinson’s and evaluate potential treatments," says Angela Cenci Nilsson.
Maria H Nilsson for her project “Motor-ACT: Motor aspects and activities in relation to cognitive decline and brain pathologies”
The overarching purpose is to improve early detection of people at risk of cognitive decline, and to determine how different motor aspects and dual tasking relate to early brain pathologies, cognitive decline, and different dementia diagnoses.
We will pinpoint motor assessments of importance for early detection to be implemented in the chain of care, so the patient gets earlier access to advanced evaluations, support, and rehabilitation," tells Maria H Nilsson.
Malin Wennström for her project “Retina-Brain Nexus: Alzheimer’s Pathogenesis and Diagnostic Approaches”
The project investigates if pathological changes characteristic of Alzheimer’s disease occur in the retina simultaneously with changes in the brain, and whether these retinal changes can be inhibited and monitored.
We aim to determine if retinal changes can be linked to Alzheimer’s and if they can be prevented," explains Malin Wennström.
Jacob Vogel for receiving a starting grant for his project “Leveraging Alzheimer’s disease subtypes toward novel biological insight and precision medicine”
Earlier work revealed that Alzheimer’s disease accumulates in the brains of patients in four different patterns, or subtypes. This proposal will build tools to help clinicians to classify patients into these subtypes and investigate their clinical progression over four years. Further, it will investigate novel proteomic biomarkers hopefully revealing biological drivers of this variation.
We hope this will be a step toward precision medicine in management and treatment of Alzheimer’s disease," explains Jacob Vogel.
Oxana Klemtentieva who received support for a project involving
international collaborations in neurodegenerative diseases (JPND) for her project “Integrating multimodal, multiscale imaging and artificial intelligence for early amyloid detection in their native environment”
Current understanding of the molecular mechanisms triggering Alzheimer’s disease remains limited. This project presents a multimodal imaging approach, powered by artificial intelligence, to uncover spatiotemporal patterns, detect early structural changes, and characterize molecular structures in their native environments, providing crucial insights for developing new anti-amyloid interventions.
We aim at detecting early structural changes that provide insights for developing new anti-amyloid interventions," says Oxana Klemtentieva.
See the complete list of awarded projects from the Swedish Research Council and the JPND (pages in Swedish).
