Translational Neurogenetics

Our research

We focus on finding protective factors for neurodegenerative disorders, with emphasis on Parkinson’s disease (PD). Our strategy is to identify risk factors in genes, lifestyle and environment, to learn about the underlying causes for disease, and how to interfere with these.

In this quest, we combine molecular biology with in vitro and in vivo models and studies in clinical materials. Some of our ongoing projects include the characterization of a potential population-specific risk gene for PD in the Swedish population and transcriptomic profiling of Parkinson-like neurodegeneration in the substantia nigra. Additionally, we conduct studies focusing on the interaction between the peripheral immune system, neuroinflammation, and neurodegeneration.

Aims

To identify genetic risk factors for PD through case-control studies on a local, regional and global scale.
To determine the genetic cause behind resistance to Parkinson-like neurodegeneration.
To characterize the impact of local and systemic immune responses on pathology in models of PD.

Impact

Our research combines studies in experimental models with clinical materials in order to better understand the underlying cause of disease. The results will contribute to the development of new treatments that can slow down and preferably stop the progressive nature of neurodegenerative disorders, such as Parkinson’s disease.

How our research contributes to the goals of MultiPark

Our research aims to understand the origins and progression of neurodegenerative disease. The gained knowledge will contribute to creating new therapeutic approaches for prevention, disease modification, and management of unmet medical needs. From our human genetic analyses, the results can also serve to develop early and differential diagnostics and prognostics on an individual level. Our research primarily addresses the aim of MultiPark's working group 1.